对４６例畸精症患者染色体及其配偶反复流产、死胎的情况进行了分析，发现１例常染色体易位，１１例伴有大Ｙ染色体，其大Ｙ发生率明显高于正常人群。伴有大Ｙ染色体的畸精症患者，其配偶流产或死胎的频率高于染色体正常的患者。表明畸精症、流产和兄胎的发生与Ｙ染色体的变异有关。 In 46 cases of teratospermia chromosomes and their spouses recurrent miscarriage and stillbirth were analyzed and found that 1 case of autosomal translocations, 11 cases associated with large Y chromosome, the incidence of large Y was significantly higher than the normal population. Tachyzoites with large Y chromosomes have a higher frequency of spousal or stillbirth than those with normal chromosomes. Shows that the incidence of teratospermia, miscarriage and the relationship between fetal and Y chromosome mutation.