目的观察大剂量甲基泼尼松龙冲击治疗重症特发性血小板减少性紫癜（ＩＴＰ）的疗效。方法甲基泼尼松龙每天静滴２０～３０ｍｇ·ｋｇ－１，连续３天，继以泼尼松维持，治疗５５例患者。结果５５例患者出血症状得到良好的控制，血小板升高，完全反应率为２５４５％，部分反应率为４５４５％，总有效率为７０９０％；血小板升高时间为４～１４天。结论大剂量甲基泼尼松龙冲击治疗是重症ＩＴＰ患者较安全有效的方法。 Objective To observe the effect of high dose methylprednisolone shock treatment of severe idiopathic thrombocytopenic purpura (ITP). Methods Methylprednisolone was given intravenously 20 ~ 30 mg · kg-1 every day for 3 consecutive days, followed by prednisone to treat 55 patients. Results Hemorrhagic symptoms in 55 patients were well controlled. The thrombocytopenia was increased, the complete response rate was 2545%, the partial response rate was 4545% and the total effective rate was 7090%. The platelet rise time was 4 ~ 14 day. Conclusion High-dose methylprednisolone impact therapy is a safe and effective method for severe ITP patients.