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目的:探讨影响晚期非小细胞肺癌(NSCLC)预后的相关因素,为NSCLC的治疗提供参考。方法:对72例ⅢA～Ⅳ期NSCLC患者的临床资料进行回顾性分析,对晚期NSCLC预后的相关因素进行Logistic回归分析,筛选影响晚期NSCLC预后的相关因素。结果:单因素分析结果显示,KPS评分、临床分期、放化疗方式、手术与否与晚期NSCLC预后有关,χ2值分别为15.421、4.676、33.124和8.932,P值分别为0.000、0.032、0.000和0.003;多因素Logistic回归法分析表明,放化疗方式、KPS评分是晚期NSCLC预后的独立因素,RR分别为2.33937和2.13642,P<0.05。结论:KPS评分、放疗和化疗结合方式是影响晚期NSCLC患者生存的独立预后因素,对这2个因素加以重点评估和合理控制,可为晚期NSCLC患者治疗方法选择以及预后判断提供可靠的指标。
Objective: To investigate the prognostic factors of advanced non-small cell lung cancer (NSCLC) and provide references for the treatment of NSCLC. Methods: The clinical data of 72 patients with stage ⅢA to Ⅳ NSCLC were retrospectively analyzed. Logistic regression analysis was performed on the prognostic factors of advanced NSCLC to screen the prognostic factors of advanced NSCLC. Results: The results of univariate analysis showed that the KPS score, clinical stage, chemoradiotherapy and chemotherapy were related with the prognosis of advanced NSCLC. The χ2 values were 15.421, 4.676, 3.124 and 8.932, respectively, P values were 0.000, 0.032, 0.000 and 0.003 Multivariate Logistic regression analysis showed that radiotherapy and chemotherapy and KPS score were independent prognostic factors for advanced NSCLC with RR of 2.33937 and 2.13642 respectively (P <0.05). Conclusion: The combination of KPS score, radiotherapy and chemotherapy is an independent prognostic factor affecting the survival of patients with advanced NSCLC. The evaluation and rational control of these two factors can provide reliable indicators for the selection of treatment and prognosis in patients with advanced NSCLC.