目的比较初/复治肺结核患者治疗过程中不良反应发生情况,为临床医生提供参考。方法整理和分析“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项课题中相关数据,分析、比较初/复治肺结核患者治疗过程中发生的不良反应类型、发生率及预后。结果在结核病治疗过程中患者肝功能异常和胃肠道反应发生率较高,分别为初治10.01%、复治6.17%和初治6.33%、复治7.10%,初治组肝功能异常发生率与复治组比较差异有统计学意义(P<0.05);关节肌肉痛发生率初治组为1.21%,复治组为2.78%,差异有统计学意义(P<0.05)。其他类型不良反应(肝功/肾功损害、血液系统、药物过敏、神经精神症状、听神经、视神经及胃肠道反应)发生率二组比较差异无统计学意义(P>0.05)。初治组肝功/肾功损害、血液系统、药物过敏、神经精神症状等不良反应出现的时间分别为66.11、56.18、45.81、37.86、44.1d,较复治组早;复治组听神经、视神经及肌肉、关节损害出现时间为87.63、27.33、50.50d,较初治组早,其中出现最早的是视神经损害。初/复治组的耐药性与不良反应的发生无关(P>0.05)。初治组有不良反应患者的治愈率为87.4%,无不良反应患者的治愈率为89.7%,差异无统计学意义(P>0.05),治愈率与复治组比较差异有统计学意义(P<0.01);复治组有不良反应病例的治愈率61.54%,无不良反应病例的治愈率为78.95%,二者差异有统计学意义(P<0.01);结论接受国标法治疗的肺结核患者初治和复治中不良反应的发生类型和时间均不同,且复治病例不良反应的发生影响预后。 Objective To compare the incidence of adverse reactions in patients with early / retreatment pulmonary tuberculosis during the course of treatment and provide reference for clinicians. Methods To organize and analyze the relevant data of major national scientific and technological issues in the prevention and treatment of major infectious diseases such as AIDS and viral hepatitis and analyze and compare the types of adverse reactions, incidence and prognosis of patients with initial / retreatment tuberculosis during treatment. Results The incidence of abnormal liver function and gastrointestinal reaction were high in patients with tuberculosis, which were respectively 10.01% for initial treatment, 6.17% for initial treatment and 6.33% for initial treatment and 7.10% for primary treatment, and the incidence of hepatic dysfunction in primary treatment group Compared with the retreatment group, the difference was statistically significant (P <0.05). The incidence of joint muscle pain was 1.21% in the initial treatment group and 2.78% in the retreatment group, the difference was statistically significant (P <0.05). The incidence of other types of adverse reactions (liver function / kidney damage, blood system, drug allergy, neuropsychiatric symptoms, auditory nerve, optic nerve and gastrointestinal reactions) was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions such as liver function / renal damage, blood system, drug allergy and neuropsychiatric symptoms in the newly diagnosed group were 66.11,56.18,45.81,37.86,44.1d, respectively, which were earlier than that in the treatment group. The auditory nerve and optic nerve And muscle, joint damage occurred 87.63,27.33,50.50d, compared with the early treatment group, which appeared the earliest optic nerve damage. The drug resistance in initial / retreatment group was not related to the occurrence of adverse reactions (P> 0.05). The cure rate of patients with adverse reactions in initial treatment group was 87.4%, and the cure rate in patients without adverse reactions was 89.7%, the difference was not statistically significant (P> 0.05), and the cure rate was significantly different from that in retreatment group (P <0.01). The cure rate of adverse reactions in retreatment group was 61.54%, the cure rate of non-adverse reactions was 78.95%, the difference was statistically significant (P <0.01) .Conclusion The tuberculosis patients The type and duration of adverse reactions in treatment and retreatment were different, and the occurrence of adverse reactions in retreatment cases affected the prognosis.