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目的 :研究慢性粒细胞性白血病患者的预后因素。方法 :采用 Hasford等提出的慢性粒细胞白血病(CML)患者预后公式 ,对 5 7例 CML患者的预后进行回顾性分析。结果 :高、中、低危组比例分别占 12 .3%、40 .3%和47.4%。低危组的 5 a生存率 (4 8.5± 9.4) % ,中危组为 (93.1± 1.1) % ,而高危组患者 5 a内全部死亡 ,其 3a生存率仅 (19.3± 6 .90 ) % ,三组之间差异有显著性 (P<0 .0 1)。三组的生存曲线在 2 a后明显分开。结论 :Hasford预后评分系统能较好预测 CML 患者的预后。在影响预后的因素中 ,脾脏肿大和外周血原始细胞对于预后判断的意义较大。
Objective: To study the prognosis of patients with chronic myeloid leukemia. Methods: The prognosis of 57 CML patients was retrospectively analyzed using the prognostic formula of patients with chronic myelogenous leukemia (CML) proposed by Hasford et al. Results: The proportion of high, middle and low risk groups accounted for 12.3%, 40.3% and 47.4% respectively. The 5-year survival rate was (4. 8.5 ± 9.4)% in the low-risk group and (93.1 ± 1.1)% in the middle-risk group, and all the patients in the high-risk group died within 5 years. The 3a survival rate was only (19.3 ± 6.90) , The difference between the three groups was significant (P <0. 01). The survival curves of the three groups significantly separated after 2 years. Conclusion: Hasford prognostic scoring system can better predict the prognosis of CML patients. In the factors that affect the prognosis, splenomegaly and peripheral blood blast cells have a greater significance for the prognosis.