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已有报道前列腺素 E_2(PGE_2)的乙醇-水溶液可预防阿司匹林和消炎痛引起的胃肠道出血。本文研究使用小剂量 PGE_2片剂对阿司匹林诱发的胃肠道出血的作用。选择20名健康男性自愿受试者,年龄18～40岁,无胃肠道出血史或长期服用皮质类固醇或其他抗炎药物。实验组(PGE_2组)11人,对照组(安慰剂组)9人。两组分别在给予阿司匹林之前24小时口服小剂量 PGE_2片剂(0.5mg,每日4次,共5日)或安慰剂。阿司匹林用量是每次2片(640mg),每日4次,共4日。用测定粪便中~(51)Cr 标记红细胞的方法检查胃肠道的出血情况。
It has been reported that ethanol-water solution of prostaglandin E2 (PGE2) can prevent gastrointestinal bleeding caused by aspirin and indomethacin. This article investigates the effect of low-dose PGE 2 tablets on aspirin-induced gastrointestinal bleeding. Twenty healthy volunteers, aged 18 to 40 years, with no history of gastrointestinal bleeding or chronic corticosteroids or other anti-inflammatory drugs, were enrolled. 11 in the experimental group (PGE 2 group) and 9 in the control group (placebo group). Two groups were given low dose PGE 2 tablets (0.5 mg four times a day for 5 days) or placebo orally 24 hours prior to aspirin administration. Aspirin dosage is 2 tablets each (640mg), 4 times a day, a total of 4 days. Gastrointestinal bleeding was examined by ~ (51) Cr-labeled erythrocytes in feces.