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目的 :探讨原发性胃肠道非霍奇金淋巴瘤临床特征和生存率的关系。方法 :对 1980 - 1997年本院收治均经病理证实的 6 6例原发于胃肠道的非霍奇金淋巴瘤患者的临床资料进行回顾性分析。对患者年龄、性别、有无 B症状、确诊前病程、临床分期、病理类型、免疫分型、肿块大小、浸润深度、有无淋巴结和 (或 )脏器转移、骨髓浸润、原发部位、治疗措施等 13个变量进行单因素及 Cox多因素分析 ,并采用 Kaplan- Meier法及 L og- rank检验进行生存情况统计。结果 :单因素分析表明年龄、性别、确诊前病程、原发部位与预后无明显相关性 (P>0 .0 5 ) ;无 B症状组、临床分期为 E～ E期及 E～ 1 E期组、低中度恶性组、 B细胞型、肿瘤未突破浆膜层组、瘤体直径小于 10 cm组、无淋巴结和 (或 )脏器转移组、无骨髓浸润组、行手术 +化疗组 5年生存率预后均较佳(P<0 .0 5 ) ;Cox分析表明肿瘤直径 <10 cm与≥ 10 cm组、临床分期为 E～ E期与 E～ E期组、免疫分型为B细胞与 T细胞组及手术 +化疗与单纯手术组 5年生存率比较 ,差异均具有显著性 (P<0 .0 5 )。结论 :肿瘤大小、临床分期、免疫分型、治疗措施为影响原发性胃肠道非霍奇金淋巴瘤预后的重要因素。
Objective: To investigate the relationship between the clinical characteristics and survival rate of primary gastrointestinal non-Hodgkin’s lymphoma. Methods: A retrospective analysis was performed on the clinical data of 66 patients with non-Hodgkin’s lymphoma from the gastrointestinal tract admitted to our hospital during 1980-1997. The patient’s age, gender, presence or absence of B symptoms, pre-diagnosis of disease, clinical stage, pathological type, immunophenotyping, tumor size, depth of invasion, with or without lymph node and / or organ metastases, bone marrow infiltration, primary site, treatment Measures and other 13 variables were univariate and Cox multivariate analysis, and using Kaplan-Meier method and L og-rank test for survival statistics. Results: Univariate analysis showed that age, gender, course of disease before diagnosis, primary site and prognosis had no significant correlation (P> 0.05); no B symptom group, clinical stage was E ~ E and E ~ 1E Group, low-grade malignant group, B cell type, tumor did not break serosal layer group, tumor diameter less than 10 cm group, no lymph node and / or organ metastasis group, no bone marrow infiltration group, operation + chemotherapy group 5 (P <0.05). The Cox analysis showed that the tumor diameter was less than 10 cm and ≥ 10 cm, and the clinical stage was in E ~ E and E ~ E groups. The immunophenotype was B cells Compared with the 5-year survival rate of T-cell group, operation + chemotherapy group and operation alone group, the difference was significant (P <0.05). Conclusion: The size of tumor, clinical stage, immunophenotyping and treatment are the important factors affecting the prognosis of primary gastrointestinal non-Hodgkin’s lymphoma.