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目的了解HBeAg阴性和HBeAg阳性两类慢性乙型肝炎患者临床相关因素的异同。方法对715例HBeAg阴性和HBeAg阳性的慢性乙型肝炎患者住院病历进行回顾性调查,分析这两组患者肝功能、诊断构成、HBV DNA定量以及免疫学检查、病理等指标的差异。结果HBeAg阴性组年龄较大,HBV DNA含量较低,慢性重型肝炎、肝硬化和肝癌构成比高。结论 HBeAg阴性慢性乙型近来发病率增高,患者年龄大,预后差,是今后防治的重点。
Objective To understand the similarities and differences of clinically relevant factors in two types of chronic hepatitis B patients with HBeAg-negative and HBeAg-positive. Methods The hospital records of 715 HBeAg-negative and HBeAg-positive chronic hepatitis B patients were retrospectively analyzed. The differences of liver function, diagnosis, HBV DNA quantification, immunological examination and pathology were analyzed. Results The older the HBeAg-negative group was, the lower the HBV DNA content was, and the proportion of chronic severe hepatitis, cirrhosis and hepatocellular carcinoma was high. Conclusion The recent incidence of HBeAg-negative chronic type B is high, and patients with large age and poor prognosis are the focus of future prevention and treatment.