论文部分内容阅读
目的探讨2型糖尿病(T2DM)患者骨密度(BMD)的变化规律及其相关影响因素。方法采用美国Hologic公司双能X线骨密度仪测定98例2型糖尿病患者腰椎(L1～4)、股骨颈(Neck)、沃氏区(Ward’s)骨密度,并与62例年龄、性别、体重指数相匹配的正常健康对照者作比较,观察其BMD的变化规律及其临床特点。结果T2DM患者的BMD较非糖尿病者降低,年龄、病程、空腹血糖、糖化血红蛋白、血脂、胰岛素等因素与T2DM患者的BMD变化相关。结论2型糖尿病易患骨质疏松,高龄、病程长、高血糖、高血脂、胰岛功能损害是骨质疏松发生的危险因素。
Objective To investigate the changes of bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM) and its related factors. Methods BMD of lumbar vertebrae (L1 ~ 4), neck and Ward’s in type 2 diabetes mellitus patients were measured by dual energy X-ray absorptiometry in Hologic, United States. Totally 62 patients with age, sex, weight Index of the matched normal healthy controls were compared to observe the changes of BMD and its clinical features. Results The BMD of T2DM patients was lower than that of non-diabetic patients. The factors such as age, course of disease, fasting blood glucose, glycosylated hemoglobin, lipids and insulin were correlated with the changes of BMD in T2DM patients. Conclusion Type 2 diabetes is predisposed to osteoporosis, aging, long course of disease, hyperglycemia, hyperlipidemia and islet dysfunction are the risk factors of osteoporosis.