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先天无胸腺小鼠(Nude mouse)由于它的细胞免疫缺陷,对感染的抵抗力弱并对异种组织移植无排斥反应。一般饲养容易死亡,只有在无菌条件下饲养方能长期生存。先天无胸腺小鼠接种人麻风菌后,置于维尼龙隔离器内饲养观察结果如下:上次曾报告足垫接种组的接种菌量为1.0×10~4/0.03毫升,8个月后对照组KK小鼠的增菌量为4.6×10~4/足(4.6倍),而先天无胸腺小鼠的增菌量分别为4.6×10~5(46倍)、3.3×10~5(33倍),并且后者的腹股沟淋巴结涂片查菌阳性。此次报告的是一只先天无胸腺小鼠在接种麻风菌后13个月死亡,剖检结果:接种足垫组织制成的乳剂中,其菌量为2.4×10~6(240倍),在乳剂的组织块内含有多数菌块,有的聚集形成大菌块,呈明
Nude mouse, due to its cellular immunodeficiency, is less resistant to infection and has no rejection of xenotransplantation. General feeding is easy to die, feeding only in aseptic conditions can long-term survival. Congenital athymic mice were inoculated with leprosy, and placed in a viconazole isolator. The observation results were as follows: The last inoculation group inoculated with the footpad was inoculated with 1.0 × 10 ~ 4 / 0.03 ml, and after 8 months, the control The amount of viable bacteria in group KK mice was 4.6 × 10-4 / foot (4.6 times), while that of innate athymic mice was 4.6 × 10-5 (46 times) and 3.3 × 10-5 (33 Times), and the latter’s inguinal lymph node smear positive bacteria. In this report, a congenital athymic mouse died after 13 months of inoculation with leprosy. The results of the autopsy showed that the amount of mycobacterium was 2.4 × 10 ~ 6 (240 times) In the emulsion tissue block contains the majority of bacteria, and some gathered to form a large bacteria block, showing