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最近20年来,急性白血病(急白)的治疗有了很大进步,目前儿童急性淋巴细胞性白血病(急淋)及急性非淋巴细胞性白血病(急非淋)的完全缓解率分别为95%以上及70～85%;其五年生存率则分别在60～80%及30～50%左右。近年来难治性白血病(refractory leukemia)越加受到人们的重视,虽对其定义尚不明确,一般认为,是指用常规化疗方案诱导治疗无效。在维持治疗期间复发,对多种化疗方案无反应和根据现拥有资料分析提示为预后较差的白血病类型。
In the recent 20 years, there has been a great improvement in the treatment of acute leukemia (acute white). At present, the complete remission rates of acute lymphoblastic leukemia (acute lymphoblastic leukemia) and acute non-lymphocytic leukemia (acute lymphatic leukemia) in children are above 95% And 70-85%. The five-year survival rates were 60-80% and 30-50% respectively. In recent years, refractory leukemia more and more people’s attention, though its definition is not clear, is generally believed that refers to the use of conventional chemotherapy to induce ineffective treatment. Recurrences during maintenance treatment, failure to respond to multiple chemotherapy regimens and analysis of available data suggest a poor prognosis of leukemia types.