沙门氏菌/微粒体试验是一简易、经济快速筛检致突变物的有效方法。实验证明大约80～90%的化学致癌物具有致突变性,而其假阳性率和假阴性率较低(约为10～15%范围)。自从美国加里福尼亚大学B、N、A-mes等于1975年提出使用沙门氏菌/徵粒体突变试验以发现致癌物和致突变物的方法以来,Ames试验方法已被许多国家应用于环境致癌物的监测及致癌物的体内代谢研 The Salmonella/microsome test is a simple, economical, and rapid method for screening mutagens. Experiments have shown that about 80-90% of chemical carcinogens have mutagenicity, and their false positive rate and false negative rate are low (about 10-15% range). The Ames test method has been applied to environmental carcinogens in many countries since the University of California, B, N, and A-mes, et al., proposed the use of a Salmonella/mitochondrial mutagenesis assay to detect carcinogens and mutagens in 1975. Monitoring and in vivo metabolism of carcinogens