采用急性动物实验，通过对小鼠红细胞超氧化物歧化酶（ＳＯＤ）活力，丙二醛（ＭＤＡ）含量的测定及红细胞的电泳、变形能力的分析，研究丙烯腈对小鼠红细胞膜的毒作用，探讨其毒作用机理。结果表明：丙烯腈可以降低ＳＯＤ活力，但对ＭＤＡ含量无明显影响；其对红细胞变形能力影响较小，但可明显降低细胞电泳能力，提示丙烯腈对小鼠红细胞膜有一定的毒作用。 Acute animal experiments were conducted to investigate the toxic effects of acrylonitrile on the erythrocyte membrane of mice by analyzing the activity of erythrocyte superoxide dismutase (SOD), the content of malondialdehyde (MDA) and the electrophoresis and deformability of erythrocytes , To explore its toxic mechanism. The results showed that acrylonitrile could reduce the activity of SOD, but had no effect on the content of MDA. It had little influence on the erythrocyte deformability, but could significantly reduce the cell electrophoretic capacity, suggesting that acrylonitrile had a certain toxic effect on the erythrocyte membrane.