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淋巴网细胞瘤(Hodgkins disease简称HD)是淋巴或免疫系统的恶性肿瘤。近年来对于HD和免疫的关系有进一步的了解,本文简要地介绍:①免疫与HD病因的关系;②HD时免疫异常情况;③HD的免疫治疗。免疫与HD病因的关系 HD病变一般开始于淋巴结,脾脏或胸腺,而且是出现于淋巴结及脾脏的胸腺依赖区(淋巴结的皮质旁区及脾脏的白髓)。Order等曾提出本病是由于T-淋巴细胞被病毒感染,因而改变了抗原性。未受病毒感染的T—细胞攻击被病毒感染的T细胞,引起自身的免疫反
Hodgkins disease (HD) is a malignant tumor of the lymphatic or immune system. In recent years, for further understanding of the relationship between HD and immune, this article briefly describes: ① the relationship between the immune and etiology; ② immune abnormalities in HD; ③ immunotherapy of HD. The Relationship Between Immune and HD Etiology The HD lesions generally start in the lymph nodes, spleen or thymus, and are the thymus-dependent regions of the lymph nodes and spleen (the cortical regions of the lymph nodes and the spleen white blood cells). Order et al have proposed that this disease is due to T-lymphocytes infected with the virus, thus changing the antigenicity. T-cells that are not infected with the virus attack the T-cells infected with the virus and cause their own immune response