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雌甾与过量溴反应时,不仅发生芳环的溴代,而且还发生雌二醇17β-羟基的酯化、氧化以及雌酚酮16-溴代。主要产物的结构经元素分析、红外、核磁和质谱确定。反应巾还分离出一种未知物,预示雌甾芳香A-环转变为环状二烯酮结构的可能性。
When oestrans react with an excess of bromine, not only bromination of the aromatic ring but also esterification of the 17β-hydroxy group of estradiol, oxidation and estrone 16-bromo occur. The structure of the main product was confirmed by elemental analysis, IR, NMR and MS. The reaction towel also isolated an unknown material, indicating the possibility of the female steroid A-ring into cyclic diketene structure.