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自2001年以来,双光子敏化产生单重态氧的三重态光敏剂的研究取得了一定的进展。双光子三重态光敏剂对肿瘤组织的近红外激光和红外激光的光动力治疗作用具有广阔的应用前景。本文重点分析了近些年已报道的双光子三重态光敏剂种类,如疏水性、水溶性等不同的敏化剂;介绍了可以根据分子的激发态性质、利用化学手段对双光子三重态敏化剂的性质以及光敏产生单重态氧的量子产率进行调控;概括了双光子三重态敏化剂的相对和绝对双光子横截面的测量方法;总结了双光子三重态敏化剂发展中面临的一些关键问题,并展望了双光子三重态敏化剂的发展方向。
Since 2001, two-photon sensitized singlet oxygen triplet photosensitizer made some progress. Two-photon triplet photosensitizer has broad application prospects for the photodynamic therapy of near-infrared laser and infrared laser in tumor tissue. This article focuses on the two-photon triplet photosensitizer species reported in recent years, such as hydrophobic, water-soluble and other sensitizers; introduced according to the molecular nature of the excited state, the use of chemical means of the two-photon triplet state-sensitive And the quantum yield of photogenerated singlet oxygen. The measurement methods of relative and absolute two-photon cross-section of two-photon triplet sensitizer are summarized. The development of two-photon triplet sensitizer is summarized Faced with some key issues, and looked forward to the development of two-photon triplet sensitizer.