氯胺酮致癫痫文献报道较少,不熟悉该药不良反应者易造成误诊误治.本文报告2例,并复习文献,以引起临床医师的注意.例1,女,5岁,体重17kg,无癫痫病史及癫痫病家族史.因患先天性髋关节脱位,于1993年10月22日上午9时行左髋关节钢板取出术.术前肌注阿托品0.2mg,复方氯丙嗪16mg,氯胺酮90mg(北京制药厂生产.批号90052914),30min后因麻醉不理想追加氯胺酮50mg肌注,患儿入睡.手术历时1小时.上午11时患儿清醒,出现惊恐、烦躁、呕吐,四肢肌张力高,下午4时在无任何诱因的情况下患 Ketamine-induced epilepsy literature less reported, unfamiliar with adverse reactions of the drug easily lead to misdiagnosis and mistreatment.This article reports 2 cases, and review the literature to attract the attention of clinicians.Example 1, female, 5 years old, weighing 17kg, without epilepsy History and family history of epilepsy due to congenital dislocation of the hip, at 9 o’clock on the October 22, 1993 at 9 o’clock left hip plate removal surgery preoperative intramuscular injection of atropine 0.2mg, compound chlorpromazine 16mg, ketamine 90mg ( Beijing Pharmaceutical Factory production lot number 90052914), after 30min due to anesthesia is not ideal add ketamine 50mg intramuscular injection, children fall asleep. Surgery lasted 1 hour. At 11:00 am children awake, panic, irritability, vomiting, limb muscle tension high, afternoon 4 in the case of any incentive to suffer