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目的分析中性粒细胞体积分布宽度(NVDW)与溃疡性结肠炎(UC)疾病活动之间的相关性。方法采用病例对照研究,比较2015年5月至2016年12月89例活动期UC患者、43例缓解期UC患者和132例健康对照者NVDW的差异,分析NVDW与白细胞计数(WBCs)、C反应蛋白(CRP)、红细胞沉降率(ESR)及改良的Mayo评分之间的相关性,多因素分析NVDW、WBCs、CRP、ESR与UC活动的相关性,评价NVDW判定UC活动的敏感性、特异性并确定截点值。结果活动期UC组NVDW为17.63±2.43,显著高于缓解期UC组和健康对照组(14.22±1.55,13.43±0.89,P<0.05);NVDW与WBCs、CRP、ESR及改良的Mayo评分均相关(r=0.745,P=0.013;r=0.697,P=0.025;r=0.636,P=0.048;r=0.867,P=0.001);多因素分析显示NVDW和CRP均与UC活动相关(OR=3.845,95%CI:1.762~8.389、OR=1.895,95%CI:1.106~3.249);ROC曲线分析显示NVDW判定UC活动的最佳截点值为15.32,敏感性为92.44%,特异性为89.39%。结论 NVDW与UC疾病活动相关,对UC疾病活动性评估具有较高的临床应用价值。
Objective To analyze the correlation between the neutrophil volume distribution width (NVDW) and ulcerative colitis (UC) disease activity. Methods A case-control study was conducted to compare the differences of NVDW among 89 active UC patients, 43 remission UC patients and 132 healthy controls from May 2015 to December 2016. The differences of NVDW and WBCs, (CRP), erythrocyte sedimentation rate (ESR) and modified Mayo score. The correlation between NVDW, WBCs, CRP, ESR and UC activity was analyzed by multivariate analysis. The sensitivity, specificity And determine the cut-off value. Results NVDW in active UC group was 17.63 ± 2.43, which was significantly higher than that in UC group and healthy control group (14.22 ± 1.55, 13.43 ± 0.89, P <0.05). NVDW was correlated with WBCs, CRP, ESR and modified Mayo score (r = 0.745, P = 0.013; r = 0.697, P = 0.025; r = 0.636, P = 0.048; r = 0.867, P = 0.001). Multivariate analysis showed that both NVDW and CRP were correlated with UC activity , 95% CI: 1.762-8.389, OR = 1.895, 95% CI: 1.106-3.249). The ROC curve analysis showed that the best cut-off point of UC activity was 15.32 by NVDW, the sensitivity was 92.44% and the specificity was 89.39% . Conclusion NVDW is associated with UC disease activity and has high clinical value in assessing the activity of UC disease.