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经久不愈的慢性胃溃疡是否会癌变尚有争议,但动物实验证明,溃疡周围的粘膜上皮在反复炎性刺激和修复中,再生上皮易遭致癌因素的作用而发生癌变。据日本300例早期胃癌发生发展的研究表明,溃疡癌变的发生部位以胃溃疡最好发的胃角小弯侧最多见,发病高峰在40～50岁,平均年龄为50.5岁。而胃癌的发生部位多见于肠上皮化生的幽门区,其发病高峰超过60岁,平均发病年龄59.5岁。据报道胃溃疡的癌变率为1～5％。
It is controversial whether long-standing unrecoverable chronic gastric ulcers may be cancerous, but animal experiments have shown that the mucosal epithelium around the ulcers is repeatedly susceptible to carcinogenic effects and canceration during repeated inflammatory stimulation and repair. According to the study of 300 cases of early gastric cancer development in Japan, the site of ulceration is most commonly seen on the small curved side of the gastric horn, the peak of onset is 40 to 50 years old and the average age is 50.5 years old. The site of gastric cancer is more common in the pyloric area of intestinal metaplasia, the peak incidence of more than 60 years of age, the average age of 59.5 years of age. It is reported that the cancerous rate of gastric ulcer is 1 to 5%.