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氟中毒是一种长期摄入过量的含氟物质出现以氟斑牙、氟骨症为主要临床表现的全身性慢性疾病。本文主要探讨氯胺酮对慢性氟中毒大鼠心肌和脑保护作用,为进一步研究氯胺酮对慢性氟中毒大鼠心肌和脑保护作用的分子机制提供科学的理论依据。1资料与方法1.1实验动物40只健康无特定病原体级的成年SD雄性大鼠,体重(200±25)g,由中国食品药品鉴定所(scxk(京)2011-0012),饲料购买于中国食品药品
Fluorosis is a chronic, chronic disease characterized by long-term ingestion of excessive amounts of fluoride-causing substances such as dental fluorosis and skeletal fluorosis. This paper mainly discusses the protective effect of ketamine on myocardium and brain in rats with chronic fluorosis, and provides a scientific basis for further study on the molecular mechanism of ketamine on myocardial and brain protection in chronic fluorosis rats. 1 Materials and Methods 1.1 Experimental animals 40 healthy SD rats without specific pathogen grade body weight (200 ± 25) g, by the China Food and Drug Identification Institute (scxk (Beijing) 2011-0012), feed purchased from Chinese food drug