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分离家兔胃粘膜细胞，培养48h细胞融合成片后，造成约2mm2的无细胞区，作为损伤修复模型进行实验。结果：空白对照组约48h完全修复，而肝细胞生长因子（HGF，50μg／L）组24h就修复完毕。其中对照组损伤周边的胃粘膜细胞游走速度为（16．62±0．38）μm／h，而HGF组达（23．90±0．68）μm／L（P＜0．01）；模型制作后12～24h五溴脱氧尿核苷标识率，HGF组（7．6％）约是对照组（0．5％）的15倍。表明HGF有显著促进胃粘膜细胞游走与增殖的功能。提示HGF在胃炎、胃溃疡等疾病的修复过程中可能起着重要作用。
The gastric mucosal cells of rabbits were separated and cultured for 48 hours. After the cells were fused into pieces, a cell free area of about 2 mm2 was formed, which was used as a model for injury repair. Results: The blank control group was completely repaired in about 48 hours, while the hepatocyte growth factor (HGF, 50μg / L) group was repaired in 24h. The rate of gastric mucosal cell migration in the control group was (16.62 ± 0.38) μm / h, while that in HGF group was (23.90 ± 0.68) μm / L (P <0.01). The labeling rate of pentabromodine for 12 ~ 24h after model making was about 15 times higher than that of the control group (0.5%) in the HGF group (7.6%). HGF can significantly promote gastric mucosal cell migration and proliferation function. Tip HGF in gastritis, gastric ulcer and other diseases may play an important role in the repair process.