通过观察正常兔、四氧嘧啶糖尿病兔及胰岛素（ＩＮＳ）治疗兔的血糖含量、体重和生长素受体（ＧＨＲ）含量的变化，研究ＩＮＳ、ＧＨＲ及胰岛素样生长因子－Ⅰ（ＩＧＦ－Ⅰ）三者的关系，以探讨ＩＮＳ缺乏所致生长素（ＧＨ）抵抗现象的机理。结果表明，当ＩＮＳ完全缺乏，血糖极度升高时，体重严重丢失，降至原体重的７５％，而ＧＨＲ仅降至正常值的４２％。提示，ＩＮＳ对ＧＨ促生长效应具有双调节作用，既能直接刺激ＧＨＲ生成，又可作用于受体后机制，直接促进ＩＧＦ－Ⅰ生成。 The levels of insulin, GHR and insulin-like growth factor-I (IGF-I) in rabbits with normal rabbits, alloxan-induced diabetic rabbits and insulin-treated rabbits were measured. The relationship between the three to explore the lack of insulin-induced growth hormone (GH) resistance mechanism. The results showed that when INS was completely lacking and blood glucose was extremely high, the body weight was severely lost to 75% of the original body weight, while the GHR level was only reduced to 42% of the normal value. These results suggest that INS can double-regulate the growth-promoting effect of GH, which not only directly stimulates the production of GHR, but also acts on the post-receptor mechanism to directly promote IGF-I production.