目的观察卡培他滨联合奥沙利铂治疗晚期结肠癌的近期疗效和不良反应。方法对35例晚期结肠癌采用卡培他滨2500mg/(m.2d),第1～14天,每天分2次口服;奥沙利铂130mg/m2,第1天静脉滴注,21天为1周期。结果CR3例(10%),PR13例(43.3%),NC6例(20%),PD8例(20%),有效率533%。主要不良反应为手足综合症等外周神经感觉异常、腹泻、恶心、呕吐及粒细胞减少,但均未影响化疗进行。结论卡培他滨加奥沙利铂方案治疗晚期结肠癌具有较好的近期疗效,且不良反应可耐受。 Objective To observe the short-term curative effect and side effects of capecitabine combined with oxaliplatin in the treatment of advanced colon cancer. Methods 35 cases of advanced colon cancer using capecitabine 2500mg / (m. 2d), 1 to 14 days, 2 times a day orally; oxaliplatin 130mg / m2, the first day of intravenous drip, 21 days 1 cycle. Results CR3 cases (10%), PR13 cases (43.3%), NC6 cases (20%), PD8 cases (20%), the effective rate was 533%. The main adverse reactions were hand-foot syndrome and other peripheral nerve sensory abnormalities, diarrhea, nausea, vomiting and neutropenia, but did not affect the chemotherapy. Conclusion Capecitabine plus oxaliplatin regimen has good short-term efficacy in the treatment of advanced colon cancer, and adverse reactions are tolerable.