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目的:构建基于网络理论的中药方剂药理作用配伍网络,提出一种新的研究中药方剂配伍规律的方法。方法:依据网络理论,以中药为节点(node),中药配伍关系为边(edge),通过药理实验研究,运用两因素方差分析法判定中药方剂中中药-中药之间的配伍关系,建立中药方剂药理作用配伍网络;采用网络效能、网络效能相关性等参数分析预测中药方剂的配伍规律。结果:运用网络法研究了加味生脉散抗心肌缺血再灌注损伤作用的配伍规律,结果显示,延胡索是加味生脉散起主要作用的药物,其他依次为麦冬、丹参、人参和五味子;人参-丹参作用相似,最先聚为一类,依次为麦冬-五味子聚为一类,人参-丹参、麦冬-五味子再聚为一类;人参+丹参+延胡索是加味生脉散所有组方中作用最佳的方剂;上述分析结果与验证实验基本一致。结论:运用网络理论研究中药方剂药理作用配伍规律是一种可行的新方法。
OBJECTIVE: To construct a compatibility network of traditional Chinese medicine prescriptions based on network theory and propose a new method to study the compatibility of traditional Chinese medicine prescriptions. Methods: Based on the network theory, taking the traditional Chinese medicine as the node and the compatibility of traditional Chinese medicine as the edge, pharmacokinetic studies were conducted to determine the compatibility between traditional Chinese medicine and traditional Chinese medicine by using two-way analysis of variance (ANOVA) Pharmacological compatibility network; using network performance, network performance and other parameters related to predict the compatibility of traditional Chinese medicine prescription. Results: The compatibility of Jiawei Shengmai San against myocardial ischemia reperfusion injury was studied by using the network method. The results showed that Yanhuo Suo was the main drug for Jiawei Shengmai, the other followed by Radix Ophiopogonis, Radix Salviae Miltiorrhizae, Radix Ginseng and Schisandra. Radix salviae miltiorrhizae - Radix Salviae Miltiorrhizae + Radix Cynanchi Paniculata is a group of the first group, followed by Radix Ophiopogon japonicus - Schisandra clustered into one group, Fang best prescription; the above analysis results and validation experiments are basically the same. Conclusion: It is a feasible new method to study the compatibility of pharmacological action of traditional Chinese medicine with network theory.