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目的 C-反应蛋白(CRP)预测支架植入术后非靶血管病变的进展和靶病变的再狭窄。方法测定311例慢性稳定性心绞痛患者入院时及随访时的血浆CRP浓度。所有患者经皮冠状动脉支架植入术,并于6-9个月后行冠状动脉造影随访。结果进展组患者高敏CRP浓度高于非进展组患者[1.60(0.80-3.46)mg/lvs0.96(0.55-1.87)mg/l,P<0.001]。再狭窄组患者高敏CRP浓度高于非再狭窄组患者[1.46(0.90-2.90)mg/lvs1.15(0.59-2.34)mg/l,P=0.026]。多因素回归分析显示入院时血浆CRP是非靶血管病变狭窄快速进展的独立预测因子(OR=1.207,95%CI1.073-1.357,P=0.002)。结论血浆CRP可独立预测稳定性心绞痛患者支架植入术后非靶血管病变狭窄的快速进展,但与靶病变再狭窄无关。
C-reactive protein (CRP) predicts the progression of non-target vascular lesions and restenosis of target lesions following stent implantation. Methods Plasma concentrations of CRP were measured at admission and at follow-up in 311 patients with chronic stable angina pectoris. All patients underwent percutaneous coronary stenting and follow-up coronary angiography 6-9 months later. Results Patients in the progression group had a higher level of high-sensitivity CRP than patients in the non-progression group [1.60 (0.80-3.46) mg / l vs 0.96 (0.55-1.87) mg / l, P <0.001]. Patients with restenosis had higher CRP concentrations than patients without restenosis [1.46 (0.90-2.90) mg / l vs 1.15 (0.59-2.34) mg / l, P = 0.026]. Multivariate regression analysis showed that plasma CRP on admission was an independent predictor of rapid progression of non-target vascular lesions (OR = 1.207, 95% CI1.073-1.357, P = 0.002). Conclusion Plasma CRP independently predicts rapid progression of non-target vessel stenosis after stenting in patients with stable angina, but has no correlation with target lesion restenosis.