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目的:研究精蛋白锌重组赖脯胰岛素混合注射液(50R)(优泌乐50,LM50)治疗2型糖尿病的临床疗效。方法:选择门诊与病房60例口服降糖药控制不佳的2型糖尿病患者,先进行为期10 d的优泌灵70/30导入期治疗。然后随机将患者分成A,B两组,A组改用优泌乐50,B组继续应用优泌灵70/30,每隔3 d监测血糖谱,并根据血糖调整胰岛素用量。两组患者肥胖者均使用二甲双胍,不用胰岛素促泌剂及其他口服降糖药物。治疗12周后,采用交叉研究,A,B两组互换治疗方案,胰岛素总量等量互换,口服二甲双胍不变,观察并比较12周和24周后两组空腹血糖(FBG),早餐后2 h血糖(2 h-PBG,早),晚餐后2 h的血糖(2 h-PBG,晚),糖化血红蛋白(HbA1C),发生可察觉的低血糖的次数,以及胰岛素总量等各项指标的变化,从而比较两组治疗效果。结果:A,B两组在血糖总体的控制上无显著性差异,即两组治疗后HbA1C比较无显著性差异,但在餐后血糖的控制以及低血糖的发生率上优泌乐50与优泌灵70/30有显著性差异。提示优泌乐50控制餐后2 h血糖效果更好,低血糖发生率更低。结论:优泌乐50治疗2型糖尿病疗效肯定,对餐后血糖的控制与优泌灵70/30比较存在优势,且低血糖发生率低。
Objective: To study the clinical efficacy of protamine zinc combined with insulin lispro injection (50R) (LMG50, LM50) in the treatment of type 2 diabetes mellitus. Methods: Outpatient and ward 60 cases of type 2 diabetes patients with poorly controlled oral hypoglycemic agents were selected. Patients were then randomly divided into A, B two groups, A group of gifted secrete 50, B continue to use Yougealing 70/30, monitoring of blood glucose every 3 d, and adjust the amount of insulin according to blood glucose. Two groups of patients with obesity metformin, insulin secretagogues and other oral hypoglycemic agents. After 12 weeks of treatment, the crossover study was conducted. Group A and group B were swapping treatments. The total amount of insulin was interchangeable and metformin was unchanged. After two weeks of fasting blood glucose (FBG) and breakfast (2 h-PBG, morning) after 2 h, blood glucose (2 h-PBG, night), HbA1C at 2 h after dinner, frequency of detectable hypoglycemia and total amount of insulin Index changes, so as to compare the two groups of treatment. Results: There was no significant difference in the control of total blood glucose between groups A and B, that is, there was no significant difference between the two groups in the control of HbA1C, but in the control of postprandial blood glucose and the incidence of hypoglycemia, Secretion 70/30 have significant difference. Prompt ugly secretion of 50 50 g 2 h postprandial blood glucose better, lower incidence of hypoglycemia. Conclusion: Urged 50 is effective in treating type 2 diabetes and its control over postprandial blood glucose is superior to that of uricose 70/30, and the incidence of hypoglycemia is low.