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目的蓖麻油引产餐用于妊娠晚期引产效果明显,但其作用机制不清楚。本研究通过引产餐灌服妊娠大鼠建立动物引产模型,以期了解引产餐对妊娠大鼠分娩启动和产程的影响,并初步探讨蓖麻油引产餐活性成份。方法于大鼠妊娠第18~20天灌服引产餐,观察大鼠分娩启动和分娩产程变化。利用高压液相分析蓖麻油和蓖麻油引产餐中脂肪酸成份。结果引产餐可提前妊娠大鼠分娩启动时间,缩短分娩产程。蓖麻油引产餐和蓖麻油两者脂肪酸对比结果显示,成份相同,蓖麻酸均占90%,未见花生四烯酸成份。结论引产餐对妊娠晚期大鼠具有引产、催产作用,可以利用引产餐灌服妊娠大鼠建立动物引产模型。推测蓖麻酸是引产餐启动分娩和缩短产程的活性物质。
Objective Castor oil induced labor induction of labor in late pregnancy obvious effect, but its mechanism of action is not clear. In this study, we induced the induced labor in pregnant rats by induction of labor, in order to understand the effects of induction of labor on labor initiation and labor process in pregnant rats, and to explore the active ingredients of castor oil. Methods Induction of labor was induced on the 18th to 20th days of gestation in rats, and the changes of birth process and delivery during delivery were observed. High-pressure liquid phase analysis of castor oil and castor oil leads to meal fatty acids. Results Cesarean section can be ahead of pregnancy delivery time of labor, shorten the labor process. Castor oil induced meal and castor oil fatty acid comparison between the two results showed that the same composition, ricinoleic acid accounts for 90%, no arachidonic acid composition. Conclusion induction of labor on late pregnancy with induction of labor, the role of oxytocin can use induction of labor fed pregnant rats to establish animal model of induced labor. It is speculated that ricinoleic acid is the active ingredient that starts labor and shortens labor during induction of labor.