文献报道三萜类化合物有较明显的降脂作用。六味地黄丸(片)中的泽泻、生地、茯苓、萸肉等四种中药含有三萜类化合物,因此,做以下降血脂药理实验。一、对正常大鼠血脂的影响取大鼠14只,分为两组。给药组用六味地黄片(广东佛山市制药二厂出品,批号830407A,每片0 3g)制成的混悬液,每只大鼠灌胃半片。每日1次,连续给药10日。结果表明,给药组与对照组对血清胆固醇及甘油三酯均无明显影响。二、对实验性高血脂家兔血脂的影响取家兔18只,每天用高脂食物(胆固醇0.3g/kg,多维萄葡糖0.3g/kg,甲基硫氧嘧啶5mg/kg,混于0.5g/kg猪油中)卷于白菜叶内,分个喂饲。二周后,均分为对照组和给药组。在继续喂饲高脂饲料的同时,给药 The literature reports that triterpenoids have a significant lipid-lowering effect. The four kinds of traditional Chinese medicines, including Alisma, Radix, Poria, Poria, etc. in Liuwei Dihuang Pills, contain triterpenoids. Therefore, pharmacological experiments were conducted to reduce blood lipids. First, the impact on blood lipids in normal rats Rats were divided into two groups. In the administration group, a suspension made of Liu Wei Di Huang tablets (produced by the No. 2 Factory of Foshan City, Guangdong Province, batch No. 830407A, 0.3 g per tablet) was intragastrically administered to each rat. Once daily, continuous administration was performed for 10 days. The results showed that there was no significant effect of serum cholesterol and triglyceride on the administration group and the control group. Second, the experimental high cholesterol lipids in rabbits were taken 18 rabbits daily with high-fat foods (cholesterol 0.3g/kg, glucosamine 0.3g/kg, methyl thiouracil 5mg/kg, mixed in 0.5g/kg lard) was rolled in cabbage leaves and fed one by one. Two weeks later, they were divided into a control group and a drug administration group. While continuing to feed high-fat feed, dosing