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目的分析系统性红斑狼疮(systemic lupus erythematosus,SLE)患者同型半胱氨酸(HCY)、胱抑素C(Cys-C)的变化与狼疮肾炎(lupus nephritis,LN)的关系。方法测定50例健康者和72例系统性红斑狼疮患者的血清Cls-C、HCY和肌酐(Creatinine,Cr)含量,以Cockroft Gault公式计算肾小球滤过率(Glomerulus Filtration Rate,GFR),并进行比较分析。结果 LN组Cys-C、HCY、GRF、Cr等指标均明显高于健康组(P<0.05)。LN组Cys-C、HCY与GFR呈正相关,相关系数分别为0.904、0.883,P<0.01。结论 Cys-C、HCY的联合检测可作为狼疮肾炎早期诊断的有效指标,对狼疮肾炎的发展及预后具有重要的临床意义。
Objective To analyze the relationship between homocysteine (HCY), cystatin C (Cys-C) and lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). Methods Serum levels of Cls-C, HCY and creatinine were measured in 50 healthy subjects and 72 patients with systemic lupus erythematosus. Glomerrulus Filtration Rate (GFR) was calculated by the Cockroft Gault formula For comparative analysis. Results The indexes of Cys-C, HCY, GRF and Cr in LN group were significantly higher than those in healthy group (P <0.05). Cys-C, HCY and GFR in LN group were positively correlated with correlation coefficients of 0.904 and 0.883 respectively (P <0.01). Conclusions The combined detection of Cys-C and HCY can be used as an effective indicator for the early diagnosis of lupus nephritis and has important clinical significance for the development and prognosis of lupus nephritis.