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不同种类多不饱和脂肪酸(PUFAs)在恶性肿瘤治疗中具有不同作用,n-3 PUFAs对恶性肿瘤具有促凋亡作用,而n-6 PUFAs则发挥相反的作用,该文通过概述n-3 PUFAs与n-6 PUFAs对恶性肿瘤(如乳腺癌细胞、消化道肿瘤等)的不同作用,并可能通过改变癌细胞膜脂质的流动性、空间结构及功能影响信号表达、改变癌细胞中抗凋亡因子前列腺素过氧化合成酶、影响细胞外Fas/Fas-L凋亡通路或细胞内线粒体相关凋亡通路中caspase-3表达等作用机制抑制肿瘤生长,通过改变磷脂酰肌醇3-激酶/蛋白激酶B信号通路可增加化疗药效,为妇科肿瘤的临床治疗方面提供新的治疗方向。
Different types of polyunsaturated fatty acids (PUFAs) play different roles in the treatment of malignant tumors. N-3 PUFAs have a pro-apoptotic effect on malignant tumors while n-6 PUFAs exert the opposite effect. By summarizing the effects of n-3 PUFAs And n-6 PUFAs on malignant tumors (such as breast cancer cells, digestive tract tumors, etc.), and may affect the signal expression by changing the fluidity, spatial structure and function of the lipid membrane of cancer cells to change the anti-apoptosis in cancer cells Factor prostaglandin peroxidative synthase, affecting the extracellular expression of caspase-3 in the apoptotic pathway of extracellular Fas / Fas-L or mitochondria-related apoptosis in the cell and inhibiting the tumor growth by changing the mechanism of action of phosphatidylinositol 3-kinase / protein Kinase B signaling pathway can increase chemotherapeutic efficacy and provide new therapeutic direction for the clinical treatment of gynecological tumors.