目的观察格列奇特联合二甲双胍治疗肥胖Ⅱ型糖尿病的疗效。方法120例肥胖的Ⅱ型糖尿病患者随机分成格列奇特组、二甲双胍组、格列奇特联合二甲双胍组,对照了解治疗前后血糖、血脂、胰岛素的改变情况。结果使用联合治疗后患者血糖水平明显降低,血脂降低、胰岛素抵抗明显改善。结果格列奇特联合二甲双胍治疗肥胖Ⅱ型糖尿病的疗效显著,值得推广。 Objective To observe the effect of combination of gliclazide and metformin in the treatment of obese type Ⅱ diabetes mellitus. Methods One hundred and twenty obese patients with type 2 diabetes were randomly divided into two groups: the patients in the two groups were treated with glibenclamide, metformin and glibenclamide combined with metformin. The changes of blood glucose, blood lipid and insulin before and after treatment were observed. Results After treatment with combination therapy, the blood glucose level was significantly decreased, blood lipids decreased, and insulin resistance was significantly improved. Results The combination of gliclazide and metformin in the treatment of obese type 2 diabetes has significant efficacy and is worth promoting.