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目的探讨C反应蛋白的含量对2型糖尿病出现颈动脉粥样硬化的影响及早期干预的意义。方法采用免疫透射比浊法检测血清CRP质量浓度,同时应用ALOKAα-10彩色超声诊断仪对2型糖尿病患者检测颈部动脉血管内膜的厚度、粥样斑块的数量。血清CRP浓度高的给予辛伐他丁治疗。结果2型糖尿病并颈动脉硬化及斑块形成患者C反应蛋白含量明显高于对照组(P<0.01),经辛伐他丁治疗及常规胰岛素应用血糖强化控制可以明显降低血清CRP含量。结论2型糖尿病患者CRP含量越高,越易发生动脉粥样硬化及斑块形成。辛伐他丁治疗及血糖强化控制可以明显抑制炎症反应。
Objective To investigate the effect of C-reactive protein on carotid atherosclerosis in type 2 diabetes mellitus and the significance of early intervention. Methods Serum CRP levels were detected by immunoturbidimetry. Meanwhile, the thickness of atherosclerotic plaque and the number of atherosclerotic plaque were detected in patients with type 2 diabetes mellitus by ALOKAα-10 color ultrasonic diagnostic apparatus. Serum CRP concentrations were given simvastatin. Results The level of C-reactive protein in patients with type 2 diabetes mellitus and carotid atherosclerosis and plaque formation was significantly higher than that in the control group (P <0.01). Serum CRP levels were significantly decreased after treatment with simvastatin and conventional glucose control. Conclusions The higher the CRP level in type 2 diabetic patients, the more prone to atherosclerosis and plaque formation. Simvastatin treatment and glycemic control can significantly inhibit the inflammatory response.