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作者研究了欧洲红豆杉 Taxus baccataL.叶和茎的甲醇提取物及精制生物碱部位的毒性。该植物叶和茎的甲醇提取物 TXA-1和TXB-1各用酸碱法提取得粗生物碱部位TXA-2和 TXB-2,其主要含紫杉烷。TXA-2和 TXB-2分别经硅胶柱进一步精制得TXA-3和 TXB-3。在急性毒性研究中,albino小鼠均腹腔注射单次量 TXA-1、2、3和TXB-1、2、3,测定这6种试药的 LD_(50)。给药后
The authors studied the toxicity of methanol extracts and refined alkaloids from leaves and stems of Taxus baccata L. The methanol extracts TXA-1 and TXB-1 of the plant leaves and stems were each extracted by acid-base method to obtain crude alkaloids TXA-2 and TXB-2, which mainly contained taxanes. TXA-2 and TXB-2 were further purified by silica gel column to obtain TXA-3 and TXB-3. In acute toxicity studies, albino mice were injected intraperitoneally with single doses of TXA-1, 2, 3, and TXB-1, 2, and 3, and the LD50 of these 6 reagents was determined. After administration