[Objective]To provide a theoretical basis for the development of curcumin by structural modification.[Methods]Curcumin reac-ted with acetyl chloride to generate curcumin derivatives in ice-water bath.These synthetic products were separated by using silica gel chroma-tography.[Results] The synthetic products were identified as the derivatives of curcumin by digital melting point apparatus.[Conclusions] The reaction products were characterized of high purity and high yield. [Objective] To provide a theoretical basis for the development of curcumin by structural modification. [Methods] Curcumin reac-ted with acetyl chloride to generate curcumin derivatives in ice-water bath .sese synthetic products were separated by using silica gel chroma-tography. [Results] The synthetic products were identified as the derivatives of curcumin by digital melting point apparatus. [Conclusions] The reaction products were characterized of high purity and high yield.