无胸腺和新生胸腺被切除的小鼠的肿瘤发生率不比正常小鼠高的事实,曾一度使T 淋巴细胞为中心的免疫监视理论面临严峻的考验。有人基至对是否存在针对肿瘤的免疫监视提出了疑问.1973年,Takasugi 和Herberman 分别发现人和小鼠淋巴细胞未经特异性免疫,亦无需抗体参与即能在体外杀伤某些肿瘤细胞,因而称为自然杀伤(Nk)细胞,后来的研究 The fact that mice with athymic and neonatal thymectomy have a higher incidence of tumor than normal mice once put T lymphocyte-centered immunosurveillance theories into a severe test. Some people questioned whether there is immune surveillance against tumors. In 1973, Takasugi and Herberman found that human and mouse lymphocytes were not specifically immune, and they could kill some tumor cells in vitro without the participation of antibodies. Called natural killer (Nk) cells, later studies