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在人类染色体畸变中,同源染色体22号罗伯逊易位较为罕见。作者在自然流产病因的细胞遗传学研究中,发现一连续自然流产的妇女,其丈夫外周血淋巴细胞染色体异常,经高分辨 G 带、C 带和 NOR-Ag 分析,其核型为45,XX,rob(22;22)(P11.1;P 11.1)现报告如下。病例报告先证者,女,25岁,农民。结婚2年,孕3次,第一次和第三次怀孕,均在妊娠2～3个月时自然流产。第二次怀孕3个月时,作 B 超检查,发现胎儿发育明显小于妊娠月份,且无胎动,诊断死胎,即行人工流产。查体及妇科检查无异常。血型检查“O”型,Rh 阳性,血清 A 抗体效价128。先证者丈夫,25岁,农民。身体健康,
In human chromosome aberrations, Robertsonian translocation of homologous chromosome 22 is rare. In a cytogenetic study of the etiology of spontaneous abortion, the authors found that a woman with a spontaneous abortion had a chromosomal abnormality in her husband’s peripheral blood lymphocytes. Karyotypes were 45 and XX with high-resolution G-band, C-band and NOR-Ag analysis , rob (22; 22) (P11.1; P 11.1) are reported below. Case report Proof, female, 25 years old, farmer. Married 2 years, 3 pregnancies, the first and third pregnancy, both in pregnancy 2 to 3 months when the spontaneous abortion. The second 3 months of pregnancy, for B-ultrasound and found that fetal development was significantly less than the month of pregnancy, and no fetal movement, diagnosis of stillbirth, that is, abortion. Physical examination and gynecological examination without exception. Blood group examination “O” type, Rh positive, serum A antibody titer 128. Probate husband, 25 years old, farmer. Healthy body,