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目的探索慢性肝功能衰竭的治疗方法。方法采集自体骨髓并用负收集混合法分离干细胞,采取股动脉介入方法回输干细胞。结果肝功得到部分改善。移植术后4周、8周肝功结果与术前比较均有较大程度改善,术后4周总胆红素平均值35.2±7.2umol/L,与术前胆红素平均值48.5±10.7μmol/L比较明显下降,差异显著(P<0.01)。术后8周白蛋白平均值33.6±8.6g/L,比术前白蛋白平均值28.2±9.4g/L升高明显,差异显著(P<0.01)。对照组肝功也有好转,但是总胆红素下降及白蛋白升高均不显著。结论自体骨髓干细胞移植可以使慢性肝功能衰竭得到有效治疗。
Objective To explore the treatment of chronic liver failure. Methods Autologous bone marrow was harvested and stem cells were isolated by negative collection and hybridization, and stem cells were transfused by femoral artery intervention. Results Liver function was partially improved. The results of liver function at 4 weeks and 8 weeks after transplantation showed a significant improvement compared with that before operation. The average total bilirubin at 4 weeks after operation was 35.2 ± 7.2 μmol / L, which was significantly lower than that of preoperative bilirubin (48.5 ± 10.7) μmol / L decreased significantly (P <0.01). The average value of albumin at 8 weeks after operation was 33.6 ± 8.6g / L, which was significantly higher than that of preoperative albumin (28.2 ± 9.4g / L) (P <0.01). Control group also improved liver function, but decreased total bilirubin and albumin were not significant. Conclusion Autologous bone marrow stem cell transplantation can effectively treat chronic liver failure.