胰岛素依赖性糖尿病病人补体第二途径B因子多态性的检测

来源 :免疫学杂志 | 被引量 : 0次 | 上传用户:XFJ1988
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用琼脂糖凝胶高压电泳继以免疫固定技术对30例胰岛素依赖性糖尿病(IDDM)病人进行了补体第二途径B因子(Bf)遗传多态性的检测。检测结果表明,IDDM病人的BfF的基因率频(0.3667)显著高于正常人(0.1159),P《0.001;且BfFF表型也较正常人显著增高,P《0.001,BfFF表型人群,IDDM发病的相对危险性(RR)为12.58。 Seventy patients with insulin-dependent diabetes mellitus (IDDM) underwent agarose gel electrophoresis followed by immunostaining for the detection of complement factor B second-order (Bf) genetic polymorphism. The results showed that the frequency of BfF gene in IDDM patients (0.3667) was significantly higher than that in normal subjects (0.1159), P <0.001, and the BfFF phenotype was significantly higher than that in normal subjects The relative risk (RR) was 12.58.
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