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目的评价胶质瘤与手机使用危险性的联系。方法计算机检索MEDLINE、Web of Science、EMBASE、EBSCO、Cochrane Library、ScienceDirect数据库;收集胶质瘤与手机使用相关的病例对照研究文献,检索时间2000-2011年,采用RevMan5.1进行Meta分析。结果 8篇病例对照研究文献纳入,规律使用手机未见有胶质瘤危险性增高;而长期使用手机10年以上者与胶质瘤发生存在联系,OR=1.24(95%CI=1.10~1.40),长期同侧使用手机发生胶质瘤危险性增加58%,OR=1.58(95%CI=1.30~1.94)。结论规律使用手机并不增高胶质瘤的发生风险,长期频繁使用手机可能增加胶质瘤发生的风险,但分析中的偏倚与混杂因子可能影响因果关系的解释。
Objective To evaluate the association between the risk of glioma and the use of mobile phones. METHODS: MEDLINE, Web of Science, EMBASE, EBSCO, Cochrane Library, ScienceDirect database were searched by computer. The case-control study articles related to the use of gliomas and mobile phones were collected. The retrieval time was from 2000 to 2011, and Meta-analysis was performed using RevMan5.1. Results Eight cases were included in the case-control study. The risk of glioma was not increased regularly using mobile phones. However, the long-term use of mobile phones for more than 10 years was associated with glioma (OR = 1.24, 95% CI = 1.10-1.40) Long-term ipsilateral use of mobile phones increased the risk of glioma 58%, OR = 1.58 (95% CI = 1.30 to 1.94). Conclusions The regular use of mobile phones does not increase the risk of glioma. Long-term frequent use of mobile phones may increase the risk of glioma. However, bias and confounding factors in the analysis may influence the explanation of causality.