为药动学和生物利用度提供数据的生物分析方法的确证是由种种技术(如回收率研究、标准化技术、方法的选择性和特异性、校正曲线的类型、灵敏度和检测限、精密度和准确度、稳定性和耐久性等)来完成的,且受到许多不同解释方法的支配。本文对各种技术手段进行了透彻的分析,并讨论了在解释有效数据时各种易犯的错误。 The corroboration of bioanalysis methods that provide data for pharmacokinetics and bioavailability is based on a variety of techniques (eg, recovery studies, standardization techniques, methodological selectivity and specificity, type of calibration curve, sensitivity and detection limits, precision and Accuracy, stability and durability, etc.) and is governed by many different interpretive methods. This article provides a thorough analysis of various technical tools and discusses various errors that can be easily committed in interpreting valid data.