血管内皮生长因子(VEGF)抑制剂能够破坏实体瘤的大部分血管系统,但是肿瘤血管真的死亡了吗?McDonald等研究发现,就像冬天里落了叶的树,这些血管的基本结构仍然保留着,抑制剂一旦停用,新的血管则迅速形成。应用VEGF抑制剂治疗肿瘤小鼠,肿瘤血管发生了戏剧性的变化,包括新血管形 Vascular endothelial growth factor (VEGF) inhibitors can destroy most of the vascular system in solid tumors, but do the tumor blood vessels really die? McDonald et al. Found that the basic structure of these blood vessels remains the same as the fallen tree in winter As soon as inhibitors were disabled, new blood vessels formed rapidly. In the treatment of tumor mice with VEGF inhibitors, there has been a dramatic change in tumor blood vessels, including neovascularization