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目的:考察拉莫三嗪联合托吡酯治疗小儿癫痫合并抑郁症的疗效。方法:选择65例小儿癫痫合并抑郁症患者随机分为两组,对照组(32例)采用托吡酯治疗,观察组(33例)在对照组基础上给予拉莫三嗪治疗。对比两组患儿癫痫控制情况、抑郁评分及不良反应情况。结果:经3个月治疗观察组癫痫治疗总有效率(93.94%)高于对照组(83.38%),差异有统计学意义(P<0.05);观察组抑郁评分(12.8±2.0)分,低于对照组(15.7±1.3)分,差异有统计学意义(P<0.05)。结论:拉莫三嗪联合托吡酯治疗小儿癫痫合并抑郁症的临床疗效较单独用药治疗更好,且能有效改善患儿抑郁情况,不良反应低。
Objective: To investigate the efficacy of lamotrigine and topiramate in the treatment of children with epilepsy and depression. Methods: Sixty-five children with epilepsy and depression were randomly divided into two groups. The control group (32 cases) was treated with topiramate. The observation group (33 cases) was given lamotrigine on the basis of the control group. The two groups of children with epilepsy control, depression score and adverse reactions. Results: The total effective rate (93.94%) of treatment group was higher than that of control group (83.38%) after 3 months treatment, the difference was statistically significant (P <0.05); depression score of observation group (12.8 ± 2.0) In the control group (15.7 ± 1.3) points, the difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of lamotrigine combined with topiramate in the treatment of children with epilepsy and depression is better than that of single drug treatment, and can effectively reduce the depression in children with low adverse reactions.