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目的：研究儿童胃幽门螺杆菌（ＨＰ）感染的特点，以及与上胃肠病的关系。方法：对１５３例因胃肠症状接受胃镜检查的有连续症状的患儿进行前瞻性、活检组织学、血清学、尿素酶法检查、并与２６５例成年患者及１８１例无症状健康儿童对照。结果：患儿ＨＰ感染率２９％，低于成年患者７１％（Ｐ＜００５），与健康儿童（３４％）无差异（Ｐ＞００５）。儿童消化性溃疡ＨＰ感染６８％，高于非溃疡组２２％（Ｐ＜００５），但显著低于成人组９８％（Ｐ＜００５）。ＨＰ相关胃炎儿童内镜无特征、组织学炎症细胞浸润活动明显。结论：儿童ＨＰ感染是溃疡致病因素，但非唯一因素，ＨＰ感染和症状无关，ＨＰ相关胃炎有一定组织学特点。
Objective: To study the characteristics of Helicobacter pylori (HP) infection in children and its relationship with upper gastrointestinal disease. Methods: A prospective, biopsy, serological and urease test was performed in 153 consecutive children with gastrointestinal symptoms who underwent gastroscopy and were compared with 265 adult patients and 181 asymptomatic healthy children. Results: The prevalence of HP in children was 29%, which was lower than 71% in adult patients (P <005) and no difference in healthy children (34%) (P> 005). HP infection in children with peptic ulcer 68% higher than non-ulcer group 22% (P <0 05), but significantly lower than the adult group 98% (P <0 05). HP-related gastritis children endoscopic features, histological inflammatory cell infiltration activity significantly. Conclusion: HP infection in children is the causal factor of ulcer, but non-unique factors, HP infection and symptoms have nothing to do, HP-related gastritis has some histological features.