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目的探讨纳洛酮治疗新生儿缺氧缺血性脑病的临床疗效。方法选择我院收治的80例缺氧缺血性脑病新生儿,随机将患儿分为观察组和对照组各40例。两组患儿均给予综合性常规治疗,观察组患者则在此基础上加用纳洛酮治疗方案。结果与对照组相比,观察组的显效率和总有效率均明显提高,而无效率明显降低;观察组行为神经评分<35分的比率明显降低,而>35分的比率明显提高,差异均具有统计学意义(P<0.05)。观察组意识、反射、肌张力恢复时间均明显短于对照组,住院时间治疗组较对照组明显缩短,两组比较差异有统计学意义(P<0.05)。观察组血清神经元特异性烯醇化酶(NSE)水平较对照组明显降低,差异均有统计学意义(P<0.01)。结论纳洛酮治疗新生儿缺氧缺血性脑病疗效显著,对改善HIE患儿临床症状、提高治愈率有积极意义,是缺氧缺血性脑病患儿的理想治疗方法之一。
Objective To investigate the clinical efficacy of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods Eighty neonates with hypoxic-ischemic encephalopathy were selected in our hospital and randomly divided into observation group and control group with 40 cases in each group. Two groups of children were given a comprehensive routine treatment, the observation group was based on the addition of naloxone treatment. Results Compared with the control group, the apparent effective rate and total effective rate of the observation group were significantly increased, but the inefficiency was significantly reduced; the ratio of the behavioral nerve score <35 points in the observation group decreased significantly, while the ratio of> 35 points significantly increased Statistically significant (P <0.05). The recovery time of consciousness, reflex and muscle tone in the observation group were significantly shorter than those in the control group, and the length of hospitalization in the treatment group was significantly shorter than that in the control group. There was significant difference between the two groups (P <0.05). The level of serum neuron specific enolase (NSE) in the observation group was significantly lower than that in the control group (P <0.01). Conclusion Naloxone treatment of neonatal hypoxic-ischemic encephalopathy significant effect, to improve the clinical symptoms of HIE children, improve the cure rate has a positive meaning, is one of the ideal treatment for children with hypoxic-ischemic encephalopathy.