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本文比较了孕激素避孕药甲醚抗孕丸(M-QG,每颗含甲地孕酮0.55毫克、醋炔醚0.88毫克)和雌激素避孕药17—环戊烷丙酸雌二醇(ECP,每毫升花生油含ECP 2.5毫克)对兔输卵管平滑肌活动的影响。输卵管壶腹部膨胀和离体峡部肌肉收缩的实验结果如下:具有加速卵子运行能力的M-QG 能减低峡部肌肉的收缩频率活动,这一现象可能是通过松弛峡部功能性括约肌而促使卵子和输卵管液比对照组提早进入子宫。酚妥拉明(α-受体阻断剂)取代M-QG 可以获得相似结果。因此,M-QG 加速卵子运行和输卵管液流可能是由于减低输卵管α-受体的活动。反之,如果兔服用M-QG 后,再注射去甲肾上腺素(α-受体激动剂),则M-QG 所引起的峡部松弛可以减弱,同时输卵管液延缓进入子宫,其结果与对照组相似。具有延缓卵子运行能力的ECP 能增加峡部活动和延迟输卵管液进入子宫。β-受体阻断剂(心得宁)能获得类似结果,这表明ECP 似乎是压抑β-受体的效应而加强了α-受体的效应,因此延迟峡部的松弛。
This article compares progesterone contraceptives, methyl ether anti-pregnancy pills (M-QG, 0.55 mg each with megesterone acetate and 0.88 mg acetylene ether) and 17-cyclopentane estradiol propionate (ECP , Peanut oil per milliliter containing ECP 2.5 mg) on the activity of the fallopian tube smooth muscle in rabbits. Tubal ampulla swelling and isolated isthmus muscle contraction results are as follows: M-QG can accelerate the operation of the egg can reduce isthmic muscle contraction frequency activity, a phenomenon that may be by relaxing isthmic functional sphincter to promote ovulation and fallopian tube fluid Early into the uterus than the control group. Similar results can be obtained by replacing M-QG with phentolamine (alpha-blocker). Therefore, M-QG accelerates the operation of the ovum and the fallopian tube fluid flow may be due to reduced tubal α-receptor activity. Conversely, if M-QG was given to rabbits and then injected with norepinephrine (α-receptor agonist), relaxation of the isthmus caused by M-QG was weakened and tubal fluid was delayed into the uterus, and the result was similar to that of the control group . ECPs that delay ovulation can increase isthmus activity and delay tubal fluid entry into the uterus. Similar results were obtained with the beta-blocker (dextromethorphan), suggesting that ECP appears to suppress the effects of beta-receptors and potentiate the effects of alpha-receptors, thus delaying isthmic relaxation.