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目的研究克心痛滴鼻剂对心肌缺血大鼠的影响。方法对垂体后叶素及冰水应激法致心肌缺血大鼠作心电图、心肌酶、SOD、MDA及血液流变学指标的观测。结果克心痛滴鼻剂可改善心肌缺血大鼠心电图表现 ,降低L DH、CK及 MDA的含量 ,升高 SOD含量 ,并改善血液流变学指标。结论克心痛滴鼻剂可改善心肌供血 ,防治心肌损伤 ,提高抗氧化能力 ,降低血液粘稠度 ,增加心肌血流量 ,从而起到防治冠心病心绞痛的作用。
Objective To investigate the effect of Kexintong nasal drops on rats with myocardial ischemia. Methods Electrocardiogram, myocardial enzyme, SOD, MDA and hemorheological parameters of rats with myocardial ischemia induced by pituitrin and ice-water stress were observed. Results Kexintong nasal drops can improve the electrocardiogram performance of rats with myocardial ischemia, reduce the content of LDH, CK and MDA, increase the content of SOD, and improve the hemorheology indexes. Conclusion Kexintong nasal drops can improve myocardial blood supply, prevent myocardial damage, increase antioxidation ability, decrease blood viscosity, increase myocardial blood flow, and thus play an important role in prevention and treatment of angina pectoris of coronary heart disease.