地高辛能引起不同的动物模型的内脏血管收缩,并能减少健康人的肝血流量。作者研究了静脉内给予地高辛0.5mg对于酒精性肝硬化和门脉高压患者的门静脉血液动力的影响。研究显示,地高辛使6名受试患者中的4名肝静脉楔压梯度(WHVPG)下降,使5名可作肝血流量(EHBF)测定的患者中的4名EHBF下降。WHVPG从24±3.4下降至20±5.8mmHg(mean±SEM;0.2>P>0.5)无统计学意义。但EHBF从14±176减少到466±113mls/分(P< Digoxin can cause visceral vasoconstriction in different animal models and can reduce hepatic blood flow in healthy people. The authors studied the effect of intravenous administration of digoxin 0.5 mg on portal hemodynamics in patients with alcoholic cirrhosis and portal hypertension. The study showed that digoxin decreased 4 WHD in 6 of 6 subjects and decreased 4 EHBFs in 5 of the 5 liver-volume-flow (EHBF) determinations. There was no significant difference in WHVPG from 24 ± 3.4 to 20 ± 5.8 mmHg (mean ± SEM; 0.2> P> 0.5). However, EHBF decreased from 14 ± 176 to 466 ± 113 mls / min (P <