目的　研究鳖甲消丸对大鼠肝纤维化的防治作用。方法　运用皮下多次注射四氯化碳致大鼠慢性损伤性肝纤维化模型 ,观察不同剂量鳖甲消丸对大鼠肝组织病理变化、血清透明质酸、血清丙氨酸氨基转移酶 (ALT/GPT)、天冬氨酸氨基转氨酶 (AST/GOT)、总蛋白 (TP)和白蛋白 (Alb)以及内脏器官重量和门脉压的影响 ,并与秋水仙碱进行了比较。结果　各剂量组的鳖甲消丸均对大鼠肝脏有一定的保护作用 ,且预防效果比秋水仙碱组好 ,但组间差异不明显。结论　鳖甲消丸可有效预防四氯化碳所致的大鼠肝纤维化作用 Objective To study the preventive and therapeutic effects of Qi Jia Xiao Yu Pills on hepatic fibrosis in rats. Methods The rat models of chronic hepatic fibrosis induced by multiple injections of carbon tetrachloride were used to observe the pathological changes of hepatic tissue, serum hyaluronic acid and serum alanine aminotransferase in rats treated with different doses of Biejia Xiaoying Pill. The effects of ALT/GPT, aspartate aminotransferase (AST/GOT), total protein (TP), and albumin (Alb), as well as visceral organ weight and portal pressure, were compared with colchicine. Results The Qijiaxiaoxiao Pills in each dose group had a certain protective effect on rat liver, and the preventive effect was better than colchicine group, but there was no significant difference between groups. Conclusion Biejia Xiaoying Pills can effectively prevent carbon tetrachloride-induced liver fibrosis in rats