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基础研究本品口服后1小时血浆前体药物浓度达峰值;2小时后活性代谢产物Benazeprilat达峰值500 pmol/g,24小时后降至10～20pmol/g。口服本品单剂20mg,ACE抑制作用维持24小时,作为抗高血压药应用时,每日只需服药1次。临床研究双盲研究证明,口服Benazepril 20mg每日1次,血压明显下降;个别病人10mg每日1次就有降压效果。40～80mg每日1次血压下降幅度仅略超过每日1次20mg。副作用副作用总发生率52%(823/1595例),最常见的为头痛、上呼吸道感染、疲劳、头昏,一般为疼痛、咳嗽加重、鼻炎、恶
Basic research 1 hour after oral administration of plasma prodrug concentration peak; 2 hours after the active metabolite Benazeprilat peak 500 pmol / g, reduced to 10 ~ 20pmol / g after 24 hours. A single oral dose of 20mg, ACE inhibitory effect for 24 hours, as an antihypertensive drug application, only a daily dose. Clinical studies Double-blind studies have shown that oral Benazepril 20mg daily 1, blood pressure decreased significantly; individual patients 10mg daily antihypertensive effect. 40 ~ 80mg daily drop in blood pressure only slightly more than once daily 20mg. Side effects A total of 52% (823/1595) cases of side effects, the most common being headache, upper respiratory tract infections, fatigue, dizziness, general pain, increased cough, rhinitis, evil