论文部分内容阅读
目的:研究不同发病孕周早发型重度子痫前期(EOSP)期待治疗时间及母儿结局。方法:将EOSP孕妇162例按发病孕周的不同分为3组:A组28~29+6周妊娠患者43例,B组30~31+6周妊娠患者52例,C组32~33+6周妊娠患者67例。各组患者入院后均严密监测血压积极治疗,如达到终止妊娠指征时立即终止妊娠。比较分析各组期待治疗时间、分娩方式及母儿并发症的情况。结果:各组患者期待治疗时间比较差异无统计学意义(P>0.05);分娩的方式均以剖宫产为主,差异无统计学意义(P>0.05)。母体子痫及心衰的发生率C组孕妇明显高于A、B两组,差异有统计学意义(P<0.01),A、B两组间比较差异无统计学意义(P>0.05)。肾功能损害及HELLP综合征的发生率各组间差异无统计学意义(P>0.05)。胎盘早剥的发生率A组明显高于B、C两组,差异有统计学意义(P<0.01);各组间围生儿死亡率A组明显高于B、C两组,差异有统计学意义(P<0.05)。随着发病孕周的增加围生儿窒息发生明显降低,3组间比较差异均有统计学意义(P<0.01)。结论:EOSP患者期待治疗的时间长短与发病孕周无相关性,剖宫产为EOSP患者首选终止妊娠方式。EOSP患者发病孕周越小,母体心衰、子痫的发生率越高,胎盘早剥的发生率随着发病孕周的增大逐渐降低;肾功能的损害及HELLP综合征、胎儿生长受限与EOSP发病孕周无明显的相关性,围生儿病死率及围生儿窒息发生率随着孕周的增加逐渐减小。
Objective: To study the expected treatment duration and maternal and infant outcomes of early onset severe preeclampsia (EOSP) in different gestational weeks. Methods: 162 pregnant women with EOSP were divided into 3 groups according to their gestational age: 43 cases in group A with 28-29 + 6 weeks of pregnancy, group B with 30-31 + 6 weeks in pregnancy, 52 cases in group C and 32-33 + 6 weeks pregnant patients 67 cases. Patients in each group were closely monitored after admission to the positive treatment of blood pressure, such as terminating pregnancy immediately terminate the pregnancy indications. Comparative analysis of each group expectant treatment time, mode of delivery and maternal and child complications. Results: There was no significant difference in expectant treatment time between the two groups (P> 0.05). Cesarean section was the main mode of delivery. The difference was not statistically significant (P> 0.05). The incidence of maternal eclampsia and heart failure in C group was significantly higher than that in A and B groups (P <0.01). There was no significant difference between A and B groups (P> 0.05). The incidence of renal dysfunction and HELLP syndrome was not significantly different between groups (P> 0.05). The incidence of placental abruption in group A was significantly higher than that in group B and C (P <0.01). The perinatal mortality rate in group A was significantly higher than that in group B and C Significance (P <0.05). The incidence of perinatal asphyxia significantly decreased with the increase of gestational age. The differences among the three groups were statistically significant (P <0.01). Conclusion: There is no correlation between the expected duration of treatment and gestational age in EOSP patients. Cesarean section is the preferred termination of pregnancy in EOSP patients. EOSP patients with smaller gestational age, maternal heart failure, the higher the incidence of eclampsia, the incidence of placental abruption decreased with the increase of gestational age; renal damage and HELLP syndrome, fetal growth restriction There was no significant correlation with the gestational age of EOSP. The incidence of perinatal mortality and perinatal asphyxia gradually decreased with the increase of gestational age.